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自三氯化鋁和異丙鋁溶液制得了氯異丙鋁.对于DL-α-乙酰氨基-β-羟基-对-硝基苯丙酮的还原速率测定表明,含有39％分子比氯異丙鋁的異丙鋁,氯異丙鋁混合物的还原能力最高。在这一改进的基础上,我們設計了反应物处理的新方法。以过量鹽酸加到經过濃縮的反应物中,使鋁成为極易溶解的三氯化鋁,而产品DL-threo-1-对-硝基苯-2-乙酰氨基-1,3-丙二醇則水解为相当的氨基化合物鹽酸鹽,冷后不溶析出,借以分离。由氨基化合物鹽酸鹽加碱,能得到对于DL-α-乙酰氨基-β-羟基-对-硝基苯丙酮来說,总收率达70％以上的游离氨基化合物。試用氯乙醇鋁还原的結果不能令人滿意.但發現氯乙醇鋁的存在大大改善了乙醇鋁的溶解度。
Chloroisopropylaluminum was prepared from aluminum trichloride and aluminum isopropylate solution.The reduction rate of DL-α-acetylamino-β-hydroxy-p-nitropropanone showed that a solution containing 39% Of aluminum isopropylate, aluminum isopropylate mixture of the highest reduction ability. Based on this improvement, we have designed a new method of reagent handling. Addition of excess hydrochloric acid to the concentrated reactant resulted in aluminum being an extremely soluble aluminum trichloride and the product DL-threo-1-p-nitrophenyl-2-acetamido-1,3-propanediol Hydrolysis of the corresponding amino compound hydrochloride, cold insoluble precipitate, to separate. The addition of an amino compound hydrochloride gives a free amino compound with a total yield of over 70% for DL-α-acetylamino-β-hydroxy-p-nitropropanone. The results of the trial reduction of aluminum chloroethylatum were unsatisfactory, but the presence of aluminum chloroethylammonium significantly improved the solubility of aluminum ethoxide.