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Rufloxacin(MF934)是长效氟喹诺酮药物,其结构同氧氟沙星相似,具有广谱抗菌活性,对多数能引起慢性前列腺炎的革兰氏阳性和革兰氏阴性菌,尤其对肠杆菌有显著抗菌活性。但是,绿脓杆菌、D族链球菌和多数厌氧菌对Rufloxacin耐药。该药的消除半衰期约30h,重复给药时血浆中未见蓄积作用。许多药物对前列腺缺乏治疗作用,主要原因是药物透入前列腺组织和前列腺分泌液中很困难,药物浓度过低。临床观察表明,Rufloxacin对细菌性前列腺炎有很高疗
Rufloxacin (MF934) is a long-acting fluoroquinolone drug with a similar structure to ofloxacin and has a broad spectrum of antibacterial activity against most Gram-positive and Gram-negative bacteria that cause chronic prostatitis, especially for Enterobacteriaceae Significant antibacterial activity. However, Pseudomonas aeruginosa, Streptococcus group D, and most anaerobic bacteria are resistant to Rufloxacin. The drug elimination half-life of about 30h, repeated administration of plasma no accumulation effect. Many drugs lack of therapeutic effect on the prostate, the main reason is that drug penetration of prostate tissue and prostate secretion is very difficult, drug concentration is too low. Clinical observations show that Rufloxacin is highly active in bacterial prostatitis