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研究目的在于确定胃食道返流患儿抑制胃酸产生所需的西米替丁剂量。采用胃内pH探针监测来评价该药的效应。方法检测27名仅有胃食道返流相关的胃肠症状和/或肺部症状的患儿。所有病人均进行了一夜食道pH控针检查。用双盲法随机口服西米替丁,23名病人给予西米替丁的剂量依次为5、7.5、10mg/kg,每8小时一次。其中8名病人因对此三种剂量反应低下,剂量增至15mg/kg,另外4名病人因以前对小剂量西米替丁反应低下,实验时给予10、15mg/kg的西米替丁。用pH控头留置胃大弯来连续监测服药后胃内pH的变
The aim of the study was to determine the dose of cimetidine required for gastric acid suppression in children with rectal reflux. The effects of this drug were evaluated by intragastric pH probe monitoring. Methods Twenty-seven children with only gastrointestinal symptoms and / or pulmonary symptoms associated with gastroesophageal reflux were examined. All patients underwent a night esophageal pH control examination. Double-blind randomized cimetidine, 23 patients given cimetidine dose followed by 5,7.5,10 mg / kg, once every 8 hours. Eight of these patients responded to these three doses with a dose increase of 15 mg / kg. The other four patients were previously treated with a low dose of cimetidine with low response rates of 10 and 15 mg / kg of cimetidine. The pH control head was used to keep the gastric curvature to continuously monitor the gastric pH change after taking the medicine