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目的：探讨外源凝集素诱导的肿瘤细胞凝集作用与转移潜能的相关性。方法：在体外测定细胞完全凝集时所需的最低凝集素浓度。结果：MMA、DSA、WGA、L－PHA和ConA等均诱导人鼻咽癌细胞凝集，但浓度不同，而且同种凝集素诱导不同转移潜能肿瘤细胞凝集的最低有效浓度之间存着差异（P＜0．05）。E－PHA也诱导不同转移潜能肿瘤细胞凝集，但凝集素浓度之间无差异（P＞0．05）。结论：MMA、DSA、WGA、L－PHA诱导的细胞凝集与转移潜能正相关；conA诱导的与转移潜能负相关；E－PHA诱导的与转移潜能不相关。这一研究结果可能有助于肿瘤的恶化程度诊断和预后以及肿瘤转移分子机制的进一步探讨。
Objective: To investigate the correlation between lectin-induced tumor cell agglutination and metastatic potential. Method: The minimum lectin concentration required for complete agglutination of cells was determined in vitro. RESULTS: MMA, DSA, WGA, L-PHA, and ConA all induced agglutination of human nasopharyngeal carcinoma cells, but the concentrations were different, and there was a difference between the lowest concentration of agglutinin-induced agglutination of different metastatic potential tumor cells (P <0.05). E-PHA also induced agglutination of tumor cells with different metastatic potentials, but there was no difference in lectin concentrations (P>0.05). CONCLUSION: The cell agglutination and metastatic potential induced by MMA, DSA, WGA, and L-PHA are positively correlated; conA-induced negative correlation with metastatic potential; E-PHA-induced metastasis is not related to metastatic potential. The results of this study may contribute to the diagnosis and prognosis of tumor progression and further discussion of molecular mechanisms of tumor metastasis.