论文部分内容阅读
5—羟色胺(5—HT)对多种动物,包括人的心率和心力有很大影响。对5—HT的初期反应主要是短期心动过缓,它因心迷走传入神经上的5—HT_3受体兴奋而启始,并由贝措尔德—雅里希样反射介导。一旦心动过缓被抑制,在不同物种中,5—HT通过不同机制和受体诱导心脏兴奋。在一些物种中,包括人类,冠状动脉舒张是经5—HT_1样受体介导,而5—HT_1样和5-HT_2受体都介导血管收缩。这可能有助于更好地估价5—HT在心血管病理学中的可能作用,并研究出对心力衰竭和冠状动脉痉挛有治疗作用,而对心脏无副作用的选择性5—HT受体激动剂和拮抗剂。
Serotonin (5-HT) has a large effect on heart rate and heart rate in a variety of animals, including humans. The initial response to 5-HT is mainly short-term bradycardia, which is initiated by the excitement of the 5-HT-3 receptor that is introduced into the nerve by the vagus nerve and is mediated by the Bezelt-Yarich-like reflex. Once bradycardia is suppressed, 5-HT induces cardiac excitement through different mechanisms and receptors in different species. In some species, including humans, coronary relaxation is mediated by 5-HT1-like receptors, whereas both 5-HT1-like and 5-HT2 receptors mediate vasoconstriction. This may help to better assess the possible role of 5-HT in cardiovascular pathology and to develop a selective 5-HT receptor agonist that has a therapeutic effect on heart failure and coronary artery spasm without side effects on the heart And antagonists.