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目的:为了解门脉高压症患者脾静脉壁的病理改变。方法:对15例门脉高压症患者切除脾叶静脉壁进行了普通染色(H.E)和免疫组织化学染色,并以外伤脾为对照,观察其病理改变。结果:15例门脉高压症脾静脉壁均有不同程度的平滑肌肥大、纤维组织增生,13例脾叶静脉壁内皮细胞、脾窦IgG、IgA、C_3、C_4阳性,阳性串为86.7％;10例外伤脾中仅1例阳性,阳性率为10.0％,且无明显的平滑肌肥大和纤维组织增生的改变。结论:门脉高压症患者门静脉系统本身的病理改变以及免疫病理损伤可能影响门脉高压的发生和发展。
Objective: To understand the pathological changes of splenic vein in patients with portal hypertension. Methods: 15 cases of portal hypertension in patients with excision of splenic vein wall were stained (H.E) and immunohistochemical staining, and trauma spleen as a control, to observe the pathological changes. Results: Fifteen patients with portal hypertension had different degrees of smooth muscle hypertrophy and fibrous tissue hyperplasia. The positive rate of IgG, IgA, C_3 and C_4 in 13 splenic vein wall endothelial cells and splenic sinus was 86.7%. Only one case of spleen in the case of injury was positive, the positive rate was 10.0%, and no significant changes in smooth muscle hypertrophy and fibrosis. Conclusion: The pathological changes of the portal vein system in patients with portal hypertension and the immunopathological damage may affect the occurrence and development of portal hypertension.