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研究了96例冠心病(CHD)患者血浆纤维蛋白降解产物D-二聚体(D-dimer)含量的变化。对象包括急性心肌梗塞44例(AMI组),陈旧性心肌梗塞16例(OMI组),不稳定型心绞痛21例(UA组),稳定型心绞痛15例(SA组),健康中、老年人20例(对照组)。结果AMI、OMI、UA组的D-dimer含量较对照组有显著增高,其含量分别为(1.89±1.62)、(0.92±0.89)、(1.03±0.98)mg/L(均为P<0.01)。而SA组与对照组无显著差异(P<0.05)。认为冠心病患者血浆D-dimer的变化,可作为诊断继发性纤溶的较好的指标,以及CHD体内血栓前状态和溶栓治疗的指标。
The changes of plasma fibrin degradation product D-dimer in 96 patients with coronary heart disease (CHD) were studied. The subjects included AMI group, 16 cases of old myocardial infarction (OMI group), 21 cases of unstable angina pectoris (UA group), 15 cases of stable angina pectoris (SA group), 20 cases of healthy middle-aged and elderly people Example (control group). Results The D-dimer levels in AMI, OMI and UA groups were significantly higher than those in control group (1.89 ± 1.62, 0.92 ± 0.89 and 1.03 ± 0.98 mg / L, respectively, P <0.01) . There was no significant difference between SA group and control group (P <0.05). The change of plasma D-dimer in patients with coronary heart disease can be regarded as a good indicator to diagnose secondary fibrinolysis, as well as the index of thrombotic state and thrombolytic therapy in CHD.