论文部分内容阅读
酒精性肝病(alcoholic liver disease,ALD)的发生发展过程与体内多种细胞因子有关,尤其是肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和转化生长因子-β(transforming growth factor-β,TGF-β)在调节肝细胞的凋亡过程中具有重要作用。TNF-α可引起肝细胞凋亡与炎症反应等,抗TNF-α治疗能明显减轻酒精引起的肝损害;TGF-β具有增加细胞外基质的合成和抑制细胞外基质降解的作用,TGF-β1升高与肝纤维化密切相关。细胞因子可能是防治酒精性肝病的有效分子靶点。
The development and progression of alcoholic liver disease (ALD) are related to various cytokines in vivo, especially tumor necrosis factor-α (TNF-α) and transforming growth factor-β -β, TGF-β) play an important role in the regulation of hepatocyte apoptosis. TNF-α can cause hepatocyte apoptosis and inflammatory response, anti-TNF-α treatment can significantly reduce alcohol-induced liver damage; TGF-β can increase the synthesis of extracellular matrix and inhibit the degradation of extracellular matrix, TGF-β1 Elevated liver fibrosis is closely related. Cytokines may be effective molecular targets for prevention and treatment of alcoholic liver disease.