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目的 :评估减肥药西布曲明的近期疗效和安全性。方法 :单纯性肥胖患者 6 5例 ,每天口服西布曲明胶囊 10mg,2 4周后观察服药前后体重变化和常规实验室检查结果以评价药物的疗效和安全性。结果 :从第 4周体重开始下降。经过 2 4周治疗 ,体重平均下降 2 .6 8kg(2～ 7.2kg) ,腰围减少 5 .37cm(2～ 17cm) ,臀围减少 5 .6 9cm(2～ 14cm)。患者的三酰甘油 ,总胆固醇 ,低密度脂蛋白也显著降低 ,高密度脂蛋白升高 (P <0 .0 1) ,脂肪率也有明显降低。其常见的不良反应有口干 ,口苦 ,便秘等 ,无严重的不良反应。结论 :西布曲明治疗单纯性肥胖是有效和安全的。
OBJECTIVE: To evaluate the short-term efficacy and safety of diet sibutramine. Methods: Sixty-five patients with simple obesity were given orally sibutramine capsules 10 mg daily for 24 weeks. The changes of body weight and routine laboratory tests were observed before and after treatment to evaluate the efficacy and safety of the drugs. Results: Weight loss started at week 4. After 24 weeks of treatment, the average body weight decreased by 2.68kg (2 ~ 7.2kg), waist circumference decreased by 5.37cm (2-17cm), and hip circumference decreased by 5.96cm (2-4cm). Patients with triglyceride, total cholesterol, low density lipoprotein was also significantly lower, high-density lipoprotein (P <0.01), fat rate also significantly reduced. The common adverse reactions are dry mouth, mouth pain, constipation, etc., no serious adverse reactions. Conclusion: Sibutramine is effective and safe in the treatment of simple obesity.