Synthesis and glycosidase inhibition of C-7 modified casuarine derivatives

• 作 者: Bin Cheng Yuki Hirokami Yi-Xian Li Atsushi Kato Yue-Mei Jia Chu-Yi Yu
• 机 构: Beijing National Laboratory for Molecular Science(BNLMS), CAS Key Laboratory of Molecular Recognitio
• 出 处: Chinese Chemical Letters
• 发表日期: 2017年08期
• 关键词: analogues amide completion sharp silica methanol dissolved removed spectrometer

A series of C-7 modified analogues of casuarine have been synthesized from sugar-derived nitrone and assayed against various glycosidases. Introduction of C-7 aminomethyl or amide group led to sharp decrease of the inhibitory activities.

A series of C-7 modified analogues of casuarine have been synthesized from sugar-derived nitrone and assayed against various glycosidases. Introduction of C-7 aminomethyl or amide group led to sharp decrease of the inhibitory activities.