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目的 探讨2016年-2017年马鞍山市人民医院鲍曼不动杆菌耐药性, 为临床合理应用抗菌药物提供参考.方法 分析2016年-2017年该院前5位细菌排名和多重耐药菌监测情况以及鲍曼不动杆菌耐药情况、抗菌药物使用强度 (Defined Daily Dose System, DDDs) 与各细菌耐药性相关性.结果 2016年-2017年该院前5位细菌分别为大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌、金黄色葡萄球菌, 其细菌耐药性呈逐年上升趋势;鲍曼不动杆菌对喹诺酮类抗生素、碳青霉烯类抗生素以及头孢类抗生素的耐药性较高, 耐药性普遍高于其敏感性;阿米卡星, 替加环素和米诺环素敏感性较高而耐药性较低;阿莫西林钠克拉维酸钾DDDs与鲍曼不动杆菌耐药性呈负相关, 左氧氟沙星DDDs与鲍曼不动杆菌耐药性呈正相关.结论 2016年-2017年该院鲍曼不动杆菌耐药性呈逐年上升趋势, 对抗菌药物均有不同程度耐药, 呈泛耐药现象, 临床应加强细菌耐药性监测, 根据监测结果使用抗生素, 以减缓耐药菌株的产生与传播.“,”Objective To investigate the drug resistance of acinetobacter baumanii in the intensive care unit (ICU) of Ma′anshan People′s Hospital between 2016 and 2017 in order to provide reference for clinical rational use of antibiotics.Methods The patients admitted to the hospital between January 2016 and December 2017 were selected as subjects.The top-five strains of bacteria, surveillance of multi-drug resistantbacteria, drug resistance of acinetobacter baumannii, and correlations between the defined daily dose system (DDDs) of antibiotics and bacterial resistance were analyzed.Results The top-five strains of bacteria in the hospital from 2016 to 2017 were escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, acinetobacter baumannii and staphylococcus aureus.Bacterial resistance tended to increase year by year.Acinetobacter baumannii had higher drug resistance to quinolone, carbapenem and cephalosporin antibiotics, and their drug resistance was generally higher than their sensitivity.Amikacin, tigecycline and minocycline had higher sensitivity and lower drug resistance.The DDDs of amoxicillin sodium and clavulanate potassium had negative correlations with drug resistance of acinetobacter baumannii, whereas the DDDs of levofloxacin had positive correlations with drug resistance of acinetobacter baumannii.Conclusion The drug resistance of acinetobacter baumannii to antibiotics in the hospital between 2016 and2017 rose year by year.The degree of resistance varied and pan-drug resistance seemed to exist.Therefore, it is necessary to strengthen the monitoring of bacterial resistance and rationally use antibiotics according to the results so as to inhibit the generation and transmission of drug-resistant strains.