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Tumor-targeted magnetic hyperthermia has recently attracted much attention. Magnetic nanoparticles (NPs) are heat mediator nanoprobes in magnetic hyperthermia for cancer treatment. In this paper, single cubic spinel structural Zn0.3Fe2.7O4 magnetic NPs with sizes of 14 nm-20 nm were synthesized, followed by coating with SiO2 shell. The SLP value of Zn0.3Fe2.7O4/SiO2 NPs below 20 nm changes non-monotonically with the concentration of solution under the alternating current (AC) magnetic field of 430 kHz and 27 kA/m. SLP values of all Zn0.3Fe2.7O4/SiO2 NPs appear a peak value with change of solution concentration. The solution concentrations with optimal SLP value decrease with increas-ing magnetic core size. This work can give guidance to the better prediction and control of the magnetic hyperthermia performance of materials in clinical applications.