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本文采用ELISA法检测170例脑血管病患者和90例健康对照血清中的IgG、IgA与IgM型ACL,其中病例组脑出血58例、出血性脑梗塞10例,单灶脑梗塞92例;多灶性脑梗塞10例。结果除病例组脑出血及出血性脑梗塞患者IgG型ACL平均结合指数(BI)与对照组同型ACL比较无明显差别外,其它各病组血清中各型ACL平均BI明显高于对照组(P<0.05和P<0.01),脑出血及出血性脑梗塞组IgA-ACL、IgM-ACL也明显高于对照组(P<0.01)。出血性脑梗塞IgA、IgM型ACL又明显高于脑出血(p<0.05和p<0.01)。多发性脑梗塞三型ACL显著高于单灶性脑梗塞(P<0.01);单灶性脑梗塞ACL显著高于脑出血(P<0.01)。ACL浓度变化与病情轻重呈正相关。提示ACL在脑血管病患者中出现与消失是疾病过程中机体产生的自身免疫反应,ACL的检测可作为预测中风发生或对其临床病情的估价。
In this paper, IgG, IgA and IgM ACL were detected in 170 patients with cerebrovascular disease and 90 healthy controls by ELISA, including 58 cases of cerebral hemorrhage, 10 cases of hemorrhagic cerebral infarction and 92 cases of single cerebral infarction in the case group Focal cerebral infarction in 10 cases. Results The mean BI of each type of ACL was significantly higher in the other disease groups than that in the control group (P <0.05) except for the mean IgG binding index (BI) in patients with cerebral hemorrhage and hemorrhagic cerebral infarction. <0.05 and P <0.01). The levels of IgA-ACL and IgM-ACL in cerebral hemorrhage and hemorrhagic infarction group were also significantly higher than those in control group (P <0.01). Hemorrhagic cerebral infarction IgA, IgM type ACL again significantly higher than intracerebral hemorrhage (p <0.05 and p <0.01). The ACL of multiple infarction was significantly higher than that of single focal cerebral infarction (P <0.01). The ACL of single focal cerebral infarction was significantly higher than that of intracerebral hemorrhage (P <0.01). ACL concentration changes with the severity of the disease was positively correlated. Tip ACL in patients with cerebrovascular disease appear and disappear is the body’s autoimmune response during disease, ACL detection can be used as a prediction of stroke or its clinical evaluation.