Inhibiting p38 mitogen-activated protein kinase attenuates cerebral ischemic injury in Swedish mutan

• 作 者: Liangyu Zou Haiyan Qin Yitao H
• 机 构: DepartmentofNeurology
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2012年14期
• 关键词: P38丝裂原活化蛋白激酶 淀粉样前体蛋白 转基因小鼠 缺血性脑损伤 脑缺血 突变型 瑞典 酶抑制 cerebral ischemia amyloid precu
• 基金项目: supported by the National Natural Science Foundation of China, No. 81171191,,Shenzhen Bureau of Science Technology and Information, No. 201002013,,Guangdong Province Medical Science Fund, No. A2008601

Cerebral ischemia was induced using photothrombosis 1 hour after intraperitoneal injection of the p38 mitogen-activated protein kinase (MAPK) inhibitor SB239063 into Swedish mutant amyloid precursor protein (APP/SWE) transgenic and non-transgenic mice. Th