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ABSTRACT Objective:To evaluate the antimotility activity ofEastNigerian mistletoe[Loranthus micranthus(L. micranthus)Linn] parasitic on six different host treesviz. Baphia nitida, Persia americana, Kola accuminata, Irvingia gabonensis, Citrus simensis andPentacletra macrophylla (P. mycrophylla).Methods:The antimotility of the methanol extracts and solvent fractions were evaluated in castor oil induced diarrheoa in rats.Results:The methanol extracts(200 mg/kg, i.p.) inhibited defeacation significantly(P <0.05)4 h after administration(75.73% to93.33%) more than that of atropine sulphate(2 mg/kg,i.p.) which inhibited defeacation by80.0%.The methanol extract(200 mg/kg,i.p.) ofL. micranthus parasitic onP. mycrophylla exhibited significant(P<0.05) inhibition in gastrointestinal transit(67.6%) more than that of atropine sulphate(2 mg/kg,i.p.) which inhibited gastrointestinal transit by26.4%.The solvent fractions of L. micranthus parasitic onP. mycrophylla at dose levels of150 mg/kg inhibited significantly the gastrointestinal transit of mice.FractionF5 exhibited inhibitory activity which was comparable to loperamide(73.3%). Conclusions:The methanol extract ofL. micranthus parasitic onP. macrophylla exhibits higher antimotility activity that other extracts.The solvent fractions could serve as source of novel antimotility agents.