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本文结合肝内HBsAg与HBcAg的表达情况对15例抗-HBe阳性慢性肝炎患者进行了肝细胞内HBV DNA原位杂交分析。发现其HBV感染状态可分为3种类型;①HBV活动复制型(4例,26.7％),肝内HBV DNA、HBsAg、HBcAg三者或HBsAg、HBcAg阳性;②HBV不完全复制或表达型(8例,53.3％),肝内HBV DNA、HBsAg阳性;③HBV非复制型(3例,20.0％),肝内HBV DNA及HBV标志均阴性。提示:在血清HBeAg向抗-HBe转换的病例中,HBV感染状态不尽相同,部分患者仍存在HBV活动性复制,少数病例的HBV复制已停止,半数病例处于由活动性复制相向非复制相过渡阶段。
In this paper, intrahepatic HBV DNA in situ hybridization was performed in 15 patients with anti-HBe positive chronic hepatitis by combining the expression of HBsAg and HBcAg in liver. HBV infection was found to be classified into three types: (1) HBV replication (4 cases, 26.7%), HBV DNA, HBsAg and HBcAg in liver, HBsAg and HBcAg in HBsAg positive; , 53.3%), HBV DNA and HBsAg positive in the liver; ③ HBV non-replicating (3 cases, 20.0%), HBV DNA and HBV markers in the liver were all negative. Hint: In the case of HBeAg seroconversion to anti-HBe, the status of HBV infection is not the same. Some patients still have active replication of HBV. In a few cases, HBV replication has stopped and half of cases are in transition from active replication to non-replication stage.