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目的观察血浆置换加血液滤过治疗慢性重型肝炎的临床疗效及安全性。方法将慢性重型肝炎68例,随机分成治疗组和对照组。治疗组38例在内科综合治疗的基础上,给予血浆置换治疗加血液滤过;对照组30例进行内科综合治疗,观察两组患者在治疗前后的临床症状和肝肾功能、凝血功能等相关指标及治愈好转率。结果两组对比,治疗组临床症状改善较对照组明显,治愈好转率有显著差异。(P<0.01)。结论在内科综合治疗的基础上,血浆置换加血液滤过是治疗慢性重型肝炎的安全有效方法,可以明显改善临床症状,提高生存率。
Objective To observe the clinical efficacy and safety of plasma exchange and hemofiltration in the treatment of chronic severe hepatitis. Methods 68 patients with chronic severe hepatitis were randomly divided into treatment group and control group. In the treatment group, 38 cases were treated with plasma exchange and hemodiafiltration on the basis of comprehensive medical treatment; 30 cases in the control group were treated by internal medicine, and the clinical symptoms, liver and kidney function and coagulation function were observed before and after treatment And cure improvement rate. Results The two groups were compared, the improvement of clinical symptoms in the treatment group was more obvious than that in the control group, and the improvement rate of cure was significantly different. (P <0.01). Conclusion Based on the comprehensive medical treatment, plasma exchange plus hemofiltration is a safe and effective method for the treatment of chronic severe hepatitis, which can significantly improve the clinical symptoms and improve the survival rate.