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高血压时,血管平滑肌细胞的增殖、细胞外基质的改变、内皮细胞损伤等因素均可引起血管的重构。p38丝裂原活化蛋白激酶主要介导细胞的发生、分化、增殖、凋亡等多种病理生理过程。本文简要介绍了p38丝裂原活化蛋白激酶信号转导通路与高血压血管重构的关系。
Hypertension, vascular smooth muscle cell proliferation, extracellular matrix changes, endothelial cell damage and other factors can cause vascular remodeling. p38 mitogen-activated protein kinase mainly mediates various pathophysiological processes such as cell generation, differentiation, proliferation and apoptosis. This article briefly describes the relationship between the p38 mitogen-activated protein kinase signaling pathway and vascular remodeling in hypertension.