BDNF pro-peptide：a novel synaptic modulator generated as an N-terminal fragment from the BDNF precur

• 作 者: Toshiyuki Mizui Koji Ohira Mas
• 机 构: BiomedicalResearchInst.（BMD）,LaboratoryofNutritionalBrainScience,CoreResearchforEvolutionalSciencean
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2017年7期
• 关键词: 脑源性神经营养因子 BDNF 前肽 蛋白水解 N-末端 前体 调制 突触 BDNF growth factor neural stem cells isc
• 基金项目: This work was supported by a Grant-in-Aicl for Scientific Research on Priority Areas （Elucidation of neural network function in the brain）from the Ministry of Education, Culture, Sports, Science and T

Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and pro-domain.However,compared with the expression and function of bioactive mature domain,the biological role of the pro-domain is poorly underst