The next-generation sphingosine-1 receptor modulator BAF312(siponimod) improves cortical network fun

• 作 者: Petra Hundehege Manuela Cerina
• 机 构: DepartmentofNeurologywithInstituteofTranslationalNeurology,InstituteofPhysiologyI,NovartisInstitutes
• 出 处: 中国神经再生研究:英文版
• 发表日期: 2019年11期
• 关键词: multiple SCLEROSIS FOCAL experimental autoimmune ENCEPHALOMYELITIS CORTICAL grey
• 基金项目: the Novartis Institutes of Biomedical Research,Basel,Switzerland(to SGM).

Autoimmune diseases of the central nervous system(CNS) like multiple sclerosis(MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced in the