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目的:探讨CD58/CD2在宫颈癌患者的表达水平及临床意义。方法:分别应用免疫组织化学技术及流式细胞术检测40例宫颈癌患者及30例C IN患者组织CD58水平和外周血CD2+细胞百分率,以30例子宫肌瘤患者作为正常对照。结果:宫颈癌患者外周血CD2+细胞百分率及癌组织CD58表达水平均明显低于C IN组及正常对照组,差异均具有统计学意义(P<0.05)。结论:CD58/CD2的表达与宫颈癌的发生、发展有关,二者可作为治疗及评价预后的参考指标。
Objective: To investigate the expression of CD58 / CD2 in patients with cervical cancer and its clinical significance. Methods: The levels of CD58 and percentage of CD2 + cells in peripheral blood were detected by immunohistochemistry and flow cytometry in 40 patients with cervical cancer and 30 patients with CIN. Thirty patients with uterine fibroids were used as normal controls. Results: The percentage of CD2 + cells and the expression of CD58 in peripheral blood of patients with cervical cancer were significantly lower than those in CIN and normal controls (P <0.05). Conclusion: The expression of CD58 / CD2 is correlated with the occurrence and development of cervical cancer, both of which can be used as a reference index for the treatment and evaluation of prognosis.