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目的动态研究不同剂量碘酸钾(KIO3)、碘化钾(KI)对小鼠脑组织抗氧化能力的影响。方法将240只昆明种小鼠按体重随机分为4组(各组浓度以碘离子计):(1)KI 50μg/L剂量组(对照组);(2)KI 180μg/L剂量组;(3)KIO350μg/L剂量组;(4)KIO3180μg/L剂量组。喂养10、20、30周(w)后,检测脑组织匀浆中的谷胱甘肽过氧化物酶(GPx)活性、超氧化物歧化酶(SOD)活性以及丙二醛(MDA)含量。结果与对照组相比,30 w时KI 180μg/L剂量组GPx活性降低(P<0.05),SOD/MDA降低(P<0.01);30 w时KIO3180μg/L剂量组GPx活性降低(P<0.01),SOD/MDA降低(P<0.01)。结论 30 w时与对照组相比,KI 180μg/L剂量组与KIO3180μg/L剂量组小鼠脑组织抗氧化能力均有不同程度的降低,其中KIO_3 180μg/L剂量组GPx活性降幅更大。
Objective To investigate the effects of different doses of potassium iodide (KIO3) and potassium iodide (KI) on the antioxidant capacity of brain tissue in mice. Methods 240 Kunming mice were randomly divided into 4 groups according to body weight (each group with iodine ion concentration): (1) KI 50μg / L dose group (control group); (2) KI 180μg / L dose group; 3) KIO350μg / L dose group; (4) KIO3180μg / L dose group. After feeding for 10, 20, 30 weeks (w), the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD) and malondialdehyde (MDA) Results Compared with the control group, the GPx activity was decreased (P <0.05) and the SOD / MDA was decreased at 30 w KI 180μg / L (P <0.01) ), SOD / MDA decreased (P <0.01). Conclusion Compared with the control group, the anti-oxidative ability of the KI 180μg / L and KIO3180μg / L groups of mice at 30 w decreased to some extent, especially in the KIO_3 180μg / L dose group.