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骨骼肌分泌的具有减肥作用的新激素Irisin,为Ⅲ型纤连蛋白组件包含蛋白5被酶剪切成多肽片段,受过氧化物酶体增殖受体γ辅助激活因子α(PGC-1α)调控,其通过血液循环中作用于白色脂肪细胞,刺激解耦连蛋白UCP1的表达,从而使白色脂肪细胞转变为具有分解代谢脂肪特征的棕色脂肪组织,脂肪分解代谢产生的能量以热的形式散发,从而发挥减肥作用和改善胰岛素抵抗。Irisin将会成为人类探索糖尿病发病机制的新思路和治疗的新靶点。
Irisin, a new hormone secreted by skeletal muscle, is a type Ⅲ fibronectin component that contains protein 5, which is cleaved by enzyme into polypeptide fragments. It is regulated by peroxisome proliferator-receptor γ-cofactor α (PGC-1α) It acts on white adipocytes through blood circulation and stimulates the expression of the decoupling protein UCP1 so that white adipocytes are transformed into brown adipose tissue with the characteristics of catabolized fat, and the energy generated by lipolysis is dissipated as heat Play weight loss and improve insulin resistance. Irisin will be a new target for new ideas and treatments for exploring the pathogenesis of diabetes in humans.