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①目的 探讨粒细胞集落刺激因子（Ｇ－ＣＳＦ）在急性髓细胞白血病（ＡＭＬ）化疗中对骨髓造血细胞的作用。②方法 随机选择ＡＭＬ化疗病人５１ 例，其中化疗后应用Ｇ－ＣＳＦ治疗的２７ 例为治疗组，未应用Ｇ－ＣＳＦ治疗的２４ 例为对照组，动态观察骨髓抑制期和恢复期的血细胞变化。③结果 治疗组骨髓抑制期短于对照组，差异有显著意义（ｔ＝ ２．３２，Ｐ＜ ０．０５）。两组缓解率和复发率比较，差异无显著意义（χ２＝ ２．０１０，２．０３１，Ｐ＞ ０．０５）。④结论Ｇ－ＣＳＦ对化疗后骨髓的恢复作用明显。
Objective To investigate the role of granulocyte colony-stimulating factor (G-CSF) in bone marrow hematopoietic cells in acute myeloid leukemia (AML) chemotherapy. 2 Methods Fifty-one cases of AML chemotherapy were randomly selected. Among them, 27 cases were treated with G-CSF after chemotherapy as the treatment group, and 24 cases without G-CSF treatment were the control group. The changes of blood cells during bone marrow suppression and recovery were observed dynamically. 3 Results The bone marrow suppression period in the treatment group was shorter than that in the control group, with significant differences (t = 2.32, P < 0.05). There was no significant difference in remission rate and recurrence rate between the two groups (χ2= 2.010, 2.031, P> 0.05). 4 Conclusion G-CSF has a significant effect on recovery of bone marrow after chemotherapy.