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自从Pedersen首次发表冠醚合成方法以来,如今已逐渐形成了一门新的学科——冠醚化学。在冠醚化合物的合成中,往往需要纯度较高的原料。例如,在苯并-15-冠-5的合成中,常因原料1,11-二氯-3,6,9-三氧杂一十一烷(以下简称二氯)的质量不好而严重影响产物的收率。为保证二氯具有足够好的质量用以合成冠醚,除严格控制二氯的合成与精馏条件外,还必须有简便而又行之有效的质量监测方法.本文提出了应用气相色谱法分析二氯的方法、步骤.
Since Pedersen’s first publication of the crown-ether synthesis method, a new discipline has now evolved - crown ether chemistry. In the synthesis of crown ether compounds, often require high purity raw materials. For example, in the synthesis of benzo-15-crown-5, often due to the poor quality of the raw material 1,11-dichloro-3,6,9-trioxaundecane (hereinafter referred to as dichloro) Affect product yield. In order to ensure that Dichlorohydrin has good enough quality for the synthesis of crown ether, in addition to strictly controlling the synthesis and distillation conditions of Dichloro-Dichloride, simple and effective quality monitoring methods must be provided.This paper presents the application of gas chromatography Dichloride method, steps.