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目的:观察还原型谷胱甘肽治疗慢性心力衰竭的疗效。方法:慢性心力衰竭患者91例,随机分为治疗组(47例)和对照组(44例)。对照组给予常规治疗,治疗组在常规治疗的基础上给予还原型谷胱甘肽。2组疗程均为10d。出院后随访3个月,比较2组治疗前、后左心室射血分数、左心室流出道最大血流速度、舒张早期E峰流速、舒张晚期A峰流速。结果:2组治疗后左心室射血分数、左心室流出道最大血流速度、舒张早期E峰流速较治疗前增高(P<0.05),舒张晚期A峰流速较治疗前降低(P<0.05);治疗组左心室射血分数及左心室流出道最大血流速度改善优于对照组(P<0.05)。结论:还原型谷胱甘肽治疗慢性心力衰竭疗效满意。
Objective: To observe the effect of reduced glutathione on chronic heart failure. Methods: Ninety-one patients with chronic heart failure were randomly divided into treatment group (n = 47) and control group (n = 44). The control group was given routine treatment, and the treatment group was given glutathione on the basis of routine treatment. 2 groups of treatment are 10d. The patients were followed up for 3 months after discharge. The left ventricular ejection fraction, left ventricular outflow tract maximum blood flow velocity, early diastolic E peak velocity and late diastolic A peak velocity were compared between the two groups before and after treatment. Results: The left ventricular ejection fraction, the maximum blood flow velocity in left ventricular outflow tract and the peak E peak velocity in early diastole were significantly increased in both groups (P <0.05), and the peak A velocity in late diastolic phase was lower than that before treatment (P <0.05) ; Left ventricular ejection fraction and left ventricular outflow tract maximum blood flow velocity improved better than the control group (P <0.05). Conclusion: Reduced glutathione is effective in treating chronic heart failure.