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目的研究血清可溶性凝集素样氧化低密度脂蛋白受体1(sLOX-1)在老年T2DM患者的变化及其与下肢动脉病变(PAD)的关系。方法 108例老年T2DM患者,根据踝肱指数(ABI)检测结果分为单纯T2DM组48例,PAD组60例。测定包括血清sLOX-1在内的生化指标。结果 PAD组血清sLOX-1较T2DM组升高[(87.52±8.92)vs(135.28±12.05),P<0.05];血清sLOX-1与ABI呈负相关(r=-0.621,P<0.01)。多因素Logistic回归分析显示,血清sLOX-1与PAD独立相关。结论老年T2DM合并PAD患者血清sLOX-1水平与ABI有相关性,是PAD的独立危险因素。
Objective To investigate the changes of serum soluble lectin-like oxidized low density lipoprotein receptor 1 (sLOX-1) in elderly patients with T2DM and its relationship with lower extremity arterial disease (PAD). Methods One hundred and eighty elderly patients with T2DM were divided into two groups according to the ankle brachial index (ABI): 48 cases in T2DM group and 60 cases in PAD group. Biochemical markers including serum sLOX-1 were measured. Results Serum sLOX-1 in PAD group was significantly higher than that in T2DM group [(87.52 ± 8.92) vs (135.28 ± 12.05), P <0.05]. Serum sLOX-1 was negatively correlated with ABI (r = -0.621, P <0.01). Multivariate logistic regression analysis showed that serum sLOX-1 was independently associated with PAD. Conclusion Serum sLOX-1 levels in elderly patients with T2DM complicated with PAD have correlation with ABI and are independent risk factors for PAD.