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目的:探讨老年患者心脏手术后注射氟比洛芬酯与发生心房颤动的相关性,分析作用机制。方法:采用回顾性研究方法,选取老年心脏手术患者62例的病历资料,按给药的不同分成试验组和对照组。心脏手术后,对照组使用芬太尼镇痛,试验组使用氟比洛芬酯镇痛。观察两组治疗前后血清C反应蛋白(CRP)水平变化、术后房颤发生率、术后房颤持续时间、住院时间、半年内心血管疾病发病率及药品不良反应。结果:给药后试验组血清CRP水平明显低于本组治疗前,以及对照组治疗后(P<0.05或P<0.01)。试验组术后房颤发生率、房颤持续时间均明显低于对照组(P<0.05)。两组患者术后住院时间、半年内心血管疾病发病率比较,差异无统计学意义(P>0.05)。两组药品不良反应发生率差异无统计学意义(P>0.05)。结论:心脏手术后注射氟比洛芬酯心房颤动发生率明显低于芬太尼。
Objective: To investigate the correlation between the incidence of atrial fibrillation and the incidence of atrial fibrillation after flurbiprofen axetil injection in elderly patients after cardiac surgery. Methods: A retrospective study was conducted to select the medical records of 62 elderly patients who underwent cardiac surgery. The patients were divided into experimental group and control group according to their administration. After cardiac surgery, fentanyl analgesia was used in the control group and flurbiprofen axetil was used in the experimental group. The changes of serum C-reactive protein (CRP) level, the incidence of postoperative atrial fibrillation, duration of postoperative atrial fibrillation, length of hospital stay, incidence of cardiovascular disease within six months and adverse drug reactions were observed before and after treatment. Results: Serum CRP levels in the experimental group were significantly lower than those in the control group before and after treatment (P <0.05 or P <0.01). The incidence of postoperative atrial fibrillation and the duration of atrial fibrillation in the experimental group were significantly lower than those in the control group (P <0.05). There was no significant difference in the postoperative hospital stay time and cardiovascular disease incidence between the two groups (P> 0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P> 0.05). Conclusion: The incidence of atrial fibrillation after flurbiprofen injections after cardiac surgery is significantly lower than that of fentanyl.