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通过对12例HBsAg阳性的慢性肝病患者进行以HBsAg为特异性抗原的淋巴细胞转换试验观察、发现所有患者刺激指数（CPM值）均显著降低，（P＜0．01）．证实慢性乙型肝病患者特异性细胞免疫反应功能低下,认为特异性细胞毒性T细胞（Tc）功能欠缺或低下是导致乙型肝炎慢性化的重要原因。并发现其低下程度与肝病的预后呈正相关。
In 12 cases of HBsAg-positive patients with chronic liver disease HBsAg-specific lymphocyte transformation test showed that all patients with stimulation index (CPM value) were significantly lower (P <0.01). Confirmed that chronic hepatitis B patients with specific cellular immune response dysfunction, that specific cytotoxic T cells (Tc) lack of function or low is an important cause of chronic hepatitis B. And found that the degree of low and liver disease prognosis was positively correlated.