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目的:评价新型抗精神病药物奥氮平(Ola)的非经典安定剂特性。方法:用细胞外单位放电记录技术分析中脑腹侧被盖区(VTA)和黑质致密区(SNC)多巴胺(DA)神经元自发放电活动。结果:Ola对抗小鼠攀爬行为、头部抽动行为、震颤行为及小鼠的条件回避行为,但在100mg·kg~(-1)的高剂量下仍不能诱发小鼠的僵住症。Ola增加大鼠VTA但不影响SNCDA神经元的放电活动。结论:1)Ola具有D_1/D_2,5-HT_2和M-ACh多种受体的药效学相互作用的特性;2)对抗条件回避行为和诱发僵住症的不同效应有剂量区别;3)急性给药引起细胞放电频率变化的作用部位有特异性。
PURPOSE: To evaluate the non-classical stabilizer properties of the new antipsychotic drug Ola. Methods: The spontaneous discharge activity of dopamine (DA) neurons in ventral tegmental area (VTA) and substantia nigra compact zone (SNC) was analyzed by extracellular unit discharge recording technique. Results: Ola antagonized the climbing behavior, twitch behavior, tremor behavior and avoidance behavior in mice. However, it did not induce catalepsy in mice at high doses of 100 mg · kg -1. Ola increases rat VTA but does not affect the discharge activity of SNCDA neurons. Conclusions: 1) Ola has the pharmacodynamic interaction characteristics of D_1 / D_2, 5-HT_2 and M-ACh receptors; 2) there is dose difference between the antagonistic condition avoidance and the different effects of induced catalepsy; 3) Acute administration caused changes in cell discharge frequency of the site of action specific.