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目的:观察不同孕周正常妊娠妇女的血脂及载脂蛋白水平的变化。方法:采用酶学直接测定法测定310例不同孕周正常妊娠妇女和40例正常育龄未孕妇女的TC、TG、HDL-C及LDL-C的水平,ApoAI和ApoB采用免疫透射比浊法测定。结果:正常孕妇组TC和TG从孕9周起迅速升高,与对照组比较,差异有显著性(P均<0.05),TG持续升高至孕末期,TC于第30周到达最高值,此后处于高水平状态。HDL-C和ApoAI于妊娠前半期迅速升高(P<0.05),后半期变化不大,LDL-C和ApoB早孕阶段无明显改变,分别于第16周和第14周后明显上升(P<0.05,P<0.01)至第30周达到稳态。结论:正常妊娠妇女所有脂代谢指标均值于妊娠20周后均高于正常参考值范围,孕妇处于生理性高血脂状态。
Objective: To observe the changes of blood lipids and apolipoproteins in normal pregnant women of different gestation weeks. Methods: The levels of TC, TG, HDL-C and LDL-C in 310 pregnant women with different gestational weeks and 40 normal pregnant women were measured by enzyme-linked immunosorbent assay. ApoAI and ApoB were measured by immunoturbidimetry . Results: The levels of TC and TG in normal pregnant women increased rapidly from the 9th week of pregnancy, the difference was significant (P <0.05), TG increased to the end of the third trimester, TC reached the highest value in the 30th week, Since then at a high level. The levels of HDL-C and ApoAI increased rapidly in the first trimester of pregnancy (P <0.05), but did not change in the second half of pregnancy. LDL-C and ApoB in the first trimester of pregnancy were not significantly changed (P < 0.05, P <0.01) reached the steady state by the 30th week. CONCLUSION: All the indexes of lipid metabolism in normal pregnant women are higher than the normal reference value after 20 weeks gestation, and pregnant women are in physiological hyperlipidemia state.