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目的分析并评价联合使用甲氨蝶呤与米非司酮对未破裂型异位妊娠患者的临床疗效。方法将我院自2008年12月至2011年10月期间收治的异位妊娠孕妇98例随机分成治疗组与对照组各49例,治疗组患者使用米非司酮50mg/d,连用3d,并单剂量肌内注射50mg的甲氨蝶呤;对照组仅单剂量肌内注射50mg的甲氨蝶呤。结果治疗组患者的治愈率高于对照组,差异有统计学意义(P<0.05);两组患者的副作用发生率相比差异无统计学意义(P>0.05)。结论联合应用甲氨蝶吟与米非司酮的保守疗法对于临床症状较轻、包块较小且血β-HCG低的异位妊娠患者具有理想的临床疗效,能够减轻患者的手术痛苦并提高再次妊娠可能性,该方法尤其适合于在基层医院广泛推广。
Objective To analyze and evaluate the clinical efficacy of methotrexate and mifepristone in patients with unruptured ectopic pregnancy. Methods 98 cases of ectopic pregnancy treated in our hospital from December 2008 to October 2011 were randomly divided into treatment group and control group, 49 cases each. Patients in the treatment group received mifepristone 50 mg / d for 3d, A single dose of intramuscular injection of methotrexate 50mg; control group only a single dose of intramuscular injection of methotrexate 50mg. Results The cure rate of the treatment group was higher than that of the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of side effects between the two groups (P> 0.05). CONCLUSIONS: The combination of methotrexate and mifepristone conservative therapy has the ideal clinical efficacy for patients with mild clinical symptoms, small masses and low blood β-HCG levels, which can reduce the patient’s pain and increase the surgical pain The possibility of pregnancy again, the method is particularly suitable for widespread promotion in primary care hospitals.