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目的探讨帕金森病(PD)患者血浆同型半胱氨酸(Hcy)水平与临床特征的关系。方法检测PD患者(PD组,52例)和健康体检者(对照组,62例)血浆Hcy浓度,分析PD患者血浆Hcy水平与性别、年龄的关系。结果 PD组血浆Hcy高于对照组[(16.24±6.70)μmol/L vs.(13.83±5.40)μmol/L](P<0.05)。PD组男性Hcy水平高于女性[(18.34±6.63)μmol/L vs.(14.44±6.32)μmol/L](P<0.05)。结论血浆Hcy升高可能是帕金森病的危险因素之一,其水平与PD患者性别、年龄有关。
Objective To investigate the relationship between plasma homocysteine (Hcy) levels and clinical features in patients with Parkinson’s disease (PD). Methods Plasma Hcy levels in PD patients (PD group, 52 cases) and healthy subjects (control group, 62 cases) were determined. The relationship between plasma Hcy levels and sex and age was analyzed. Results The plasma Hcy in PD group was significantly higher than that in control group [(16.24 ± 6.70) μmol / L vs. (13.83 ± 5.40) μmol / L] (P <0.05). The level of male Hcy in PD group was higher than that in female [(18.34 ± 6.63) μmol / L vs. (14.44 ± 6.32) μmol / L] (P <0.05). Conclusions The elevated plasma Hcy may be one of the risk factors for Parkinson’s disease. The level of Hcy may be related to the gender and age of PD patients.