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The proliferation response of γδT cells to the antigen from heat-treated Mycobacterium tuberculosis H37Ra(M.tb Ag)was used as a good model in γδT cell research.From preliminary research it is found that activatedNK cells positively elevated γδT cells proliferation after simulating PBMCs with M.tb Ag.To investigatedifferent behaviors of NK cells,γδNKT cells,γδT cells and relationships between these cell subsets,activationand proliferation of different cell subsets of PBMCs in response to M.tb Ag were analyzed.We demonstratedthat NK cells,γδNKT cells and γδT cells could be activated after stimulation with M.tb Ag.γδNKT cells and γδTcells proliferated while the number of NK cells decreased after 11 day-simulation with M.tb Ag.Meanwhile,atthe early time of stimulation the cytotoxicity of PBMCs was enhanced.Cellular & Molecular Immunology.2004;1(6):467-470.
The proliferation response of γδ T cells to the antigen from heat-treated Mycobacterium tuberculosis H37Ra (M. tb Ag) was used as a good model in γδ T cell research. From preliminary research it is found that activatedNK cells in 40% increase in γδT cells proliferation after simulating PBMCs with M. tb Ag.o investigated in different behaviors of NK cells, γδ NKT cells, γδ T cells and relationships between these cell subsets, activation and proliferation of different cell subsets of PBMCs in response to M. tb Ag were analyzed. We demonstrated that NK cells, γδ NKT cells γδT cells could be activated after stimulation with M. tb Ag.γδNKT cells and γδTcells proliferated while the number of NK cells decreased after 11 days-simulation with M. tb Ag.Meanwhile, atthe early time of stimulation the cytotoxicity of PBMCs was enhanced . Cellular & Molecular Immunology. 2004; 1 (6): 467-470.