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纳米材料由于具有许多独特性能(如巨大的表面效应、量子效应等),因而在生物医药、环境保护等领域有着极广阔的应用前景[1]。但有研究结果显示,部分人造纳米材料具有毒性,可以引起氧化应激、炎症反应及其他组织器官的损害[2-3]。目前有越来越多的学者开始关注纳米材料对中枢神经系统的损伤。在正常情况下,只有亲脂性物质易于通过血脑屏障,但是纳米颗粒由于其特殊理化特性,有可能通过不同的途径通过血脑屏障[4-5],进入脑实质
Nanomaterials have a very wide range of applications in the fields of biomedicine and environmental protection because of their unique properties (such as huge surface effects, quantum effects, etc.) [1]. However, some studies have shown that some artificial nanomaterials are toxic and can cause oxidative stress, inflammatory reactions and other tissue and organ damage [2-3]. At present, more and more scholars begin to pay attention to the damage of the central nervous system caused by nanomaterials. Under normal circumstances, only lipophilic substances can easily cross the blood-brain barrier, but due to their special physical and chemical properties, nanoparticles may pass through the blood-brain barrier in different ways [4-5] and enter the parenchyma