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目的:评价三氧气针疗法治疗慢性疼痛的临床疗效。方法:选择2019年1-10月北京中医药大学东直门医院国际部推拿疼痛科门诊33例慢性疼痛患者，均采用三氧气针疗法治疗，1次/周，5次为1个疗程，治疗1个疗程。采用数字模拟评分量表(Numberal Rating Scale, NRS)评估患者疼痛程度和功能活动障碍程度，并进行治疗方法的安全性评价。结果:与治疗前比较，33例患者治疗后疼痛程度评分均降低[2.0(2.0)分比7.0(3.0)分，n P<0.01)]，其中腰椎间盘突出、膝骨关节炎、腰肌劳损及其他慢性疼痛患者疼痛程度的改善情况更为明显(n P值分别为0.005、0.011、0.041、0.026)；带状疱疹后遗神经痛患者疼痛无明显改善(n P＝0.066)。与治疗前比较，33例患者治疗后功能活动障碍评分均降低[2.0(2.0)分比6.0(4.0)分，n P<0.01)]，其中腰椎间盘突出、膝骨关节炎、腰肌劳损及其他慢性疼痛患者功能活动障碍的改善情况更为明显(n P值分别为0.007、0.026、0.039、0.028)；带状疱疹后遗神经痛患者疼痛无明显改善(n P＝0.102)。全部患者治疗及随访期间均未发生不良反应及损害。n 结论:三氧气针疗法可从一定程度上缓解和控制疼痛，改善功能活动障碍，操作应用安全、可靠。“,”Objective:To explore the clinical effect of the Ozone-Acupuncture therapy on chronic pain.Methods:A total of 33 patients with chronic pain, who were treated in the Department of Massage and Pain of Dongzhimen Hospital from January 2019 to October 2019, were selected. All patients were treated with the Ozone-Acupuncture, once a week, five times for one course of treatment. After one course, the Numberal Rating Scale (NRS) was used to evaluate the movement function and pain severity. The adverse events were recorded during the treatment.Results:After treatment, the pain NRS scores of 33 patients decreased to 2.0 (2.0) from 7.0 (3.0), which the difference was statistically significant (n P<0.01) , and the patients with lumbar disc herniation, knee osteoarthritis, lumbar muscle strain and other chronic pain improved significantly (n P values were 0.005, 0.011, 0.041, 0.026), but no significant among the patients with herpes zoster neuralgia (n P=0.066). The dysfunction NRS scores decreased to 2.0 (2.0) from 6.0 (4.0), which the difference was statistically significant (n P<0.01), and the patients with lumbar disc herniation, knee osteoarthritis, lumbar muscle strain and other chronic pain was more obvious (n P values were 0.007, 0.026, 0.039, 0.028), but no significant among the patients with herpes zoster neuralgia (n P=0.102). During the follow-up period of all patients, no adverse events were found.n Conclusion:The Ozone-Acupuncture therapy can relieve pain, improve functional activity safely. However, multi-center, high-quality randomized controlled trials will be warranted in future.