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目的研究血浆B型尿钠肽(BNP)在糖尿病性心肌病早期诊断的价值。方法选取我院2014年7月-2016年7月收治的2型糖尿病性心肌病患者32例作为糖尿病性心肌病患组,32例单纯2型糖尿病为单纯糖尿病组,32例健康人作为对照组,均采用免疫发光分析法测定3组的血浆BNP水平。结果通过对比三组的糖化血红蛋白、胆固醇、三酰甘油和低密度脂蛋白胆固醇(LDL-C)的水平,显示糖尿病性心肌病患组和单纯糖尿病组的水平较对照组较高(P<0.05);糖尿病性心肌病患组患者空腹血糖(FPG)以及BNP水平均比对照组高,且两组的差异具有统计学意义(P<0.01);糖尿病性心肌病患组患者FPG、LDL-C以及BNP水平均高于单纯糖尿病组,且两组差异具有统计学意义(P<0.05)。结论BNP水平的测定可以作为临床上预测糖尿病性心肌病早期诊断和筛选的依据。
Objective To investigate the value of plasma B-type natriuretic peptide (BNP) in the early diagnosis of diabetic cardiomyopathy. Methods 32 patients with type 2 diabetic cardiomyopathy admitted to our hospital from July 2014 to July 2016 were selected as the diabetic cardiomyopathy group, 32 patients with simple type 2 diabetes mellitus as the sole diabetic group and 32 healthy people as the control group , All using immuno luminescence analysis of plasma BNP levels in three groups. Results By comparing the levels of HbA1c, cholesterol, triglyceride and low density lipoprotein cholesterol (LDL-C) in the three groups, the levels of diabetic cardiomyopathy group and simple diabetic group were significantly higher than those of the control group (P <0.05 ); FPG and BNP levels in patients with diabetic cardiomyopathy were significantly higher than those in control group, and there was significant difference between the two groups (P <0.01); FPG and LDL-C in patients with diabetic cardiomyopathy And BNP levels were higher than simple diabetic group, and the difference between the two groups was statistically significant (P <0.05). Conclusion The determination of BNP levels can be used as a basis for the early diagnosis and screening of diabetic cardiomyopathy.