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近年来,由于糖尿病的发病率在我国渐趋上升。目前此类患者常以二甲双胍作为药物治疗。近期的临床实践证实:二甲双胍很少与血浆蛋白结合,不经肝脏代谢,以原型经尿排出,主要经肾小管分泌。含碘对比剂也通过肾脏排泄,可能导致急性肾小管坏死。若患者在接受含碘对比剂后,肾脏受到损害,就可延缓二甲双胍通过肾脏的排泄,引起二甲双胍在体内蓄积,极
In recent years, due to the incidence of diabetes in our country is gradually rising. At present, such patients are treated with metformin. Recent clinical practice confirmed: metformin seldom with plasma protein binding, without liver metabolism, the prototype excreted by urine, mainly by the tubular secretion. Iodine-containing contrast agents are also excreted through the kidneys and may cause acute tubular necrosis. If patients receive iodine contrast agent, the kidneys are damaged, can delay metformin excretion through the kidneys, causing metformin accumulation in the body, pole