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本文报告2例原有恶性疾病的患儿在作骨髓移植后发生致死性肝静脉闭塞性疾病。对这些患儿的原发性疾病在移植前也采用了大剂量化疗和放疗。例1系7岁男孩,患未分化的恶性淋巴瘤。在诊断后4个月用氯化亚硝脲、环磷酰胺和阿糖胞苷强化化疗4天,继而用750拉德(中等剂量)全身放疗。再输注患者已保存的骨髓。在自体骨髓移植后3周患者肝酶增高,胆红素2.9mg％(直接1.4mg)并出现腹水,以后SGOT 1880IU/L。其后3周腹水增多,患者
This article reports two cases of malignant disease in children with autologous bone marrow transplantation for fatal hepatic vein occlusive disease. The primary disease in these children was also treated with high-dose chemotherapy and radiation before transplantation. Example 1 A 7-year-old boy with undifferentiated malignant lymphoma. Chemotherapy was boosted with nitrosamine, cyclophosphamide and cytarabine for 4 days at 4 months after diagnosis, followed by 750 rad (medium dose) systemic radiotherapy. Re-infusion of the patient\'s preserved bone marrow. Patients 3 weeks after autologous bone marrow transplantation patients with elevated liver enzymes, bilirubin 2.9mg% (1.4mg directly) and the appearance of ascites, after SGOT 1880IU / L. The subsequent 3 weeks increased ascites, the patient