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按体重计算琥珀胆碱,婴儿的需要量比成年人大,如果用量达不到充分肌松,就引起下颌僵硬、紧张。由于目前尚无单剂量琥珀胆碱的量-效曲线报道,所以作者在硫喷妥钠-芬太尼-N_2O 麻醉下,观察新生儿、婴儿和儿童注用有效剂量(ED)琥珀胆碱之后,产生50%、90%和95%抽搐高度的抑制,并划出其量-效曲线。作者选择45例儿科手术病人,其中新生儿、婴儿和儿童各15例(年龄的中位数分别为12天、5.2月和4.2岁),所有病儿均属ASA Ⅰ级,未用过对
According to body weight calculation of succinylcholine, the baby’s needs than adults, if the amount does not reach full muscle relaxation, it caused the jaw stiffness, tension. Since there is no dose-response curve reported for a single dose of succinylcholine, the authors observed neonatal, infant and childhood anesthesia with an effective dose (ED) of succinylcholine following thiopental-fentanyl-N_2O anesthesia , Produced a 50%, 90%, and 95% inhibition of convulsive heights and delineated their dose-response curves. The authors selected 45 pediatric patients with 15 newborns, infants, and children (median age, 12 days, 5.2 months and 4.2 years, respectively). All children were ASA grade I