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目的:观察柴胡疏肝散加减联合质子泵抑制剂(PPI)治疗高原地区胃食管反流病(gastroesophageal reflus disease,GERD)的疗效。方法:选取GRED患者178例,随机分为PPI组(下称对照组88例,雷贝拉唑肠溶胶囊20mg,1次/天),PPI联合柴胡疏肝散组(下称治疗组90例,雷贝拉唑肠溶胶囊20mg/天,中药150ml/次,2次/天),治疗后4周比较两组治疗前后症状评分,比较两组整体疗效、局部疗效及不良反应。结果:共178例完成实验,治疗后两组患者症状评分均降低,治疗组低于对照组,并具有统计学意义(P<0.05)。治疗组显效率、有效率均高于对照组,治疗组反流性食管炎(reflux esophagitls,RE)患者局部显效率、有效率均高于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间均未出现严重不良反应。结论:柴胡疏肝散加减联合质子泵抑制剂(PPI)能有效改善高原地区胃食管反流病患者症状,且无不良反应。
Objective: To observe the curative effect of Chaihu Shugan Decoction combined with proton pump inhibitor (PPI) in the treatment of gastroesophageal reflux disease (GERD) in the plateau area. Methods: 178 patients with GRED were selected and randomly divided into PPI group (control group, 88 cases, rabeprazole enteric-coated capsules, 20 mg once daily), PPI combined with Chaihu Shugan Powder (the treatment group 90 Cases, rabeprazole enteric-coated capsules 20mg / day, Chinese medicine 150ml / time, 2 times / day), 4 weeks after treatment, the two groups were compared before and after symptom score, the two groups overall efficacy, local efficacy and adverse reactions. Results: A total of 178 cases completed the experiment. After treatment, the symptom scores of both groups were decreased, and the treatment group was lower than the control group, with statistical significance (P <0.05). The effective rate and effective rate of the treatment group were significantly higher than that of the control group. The local effective rate and effective rate of reflux esophagitis (RE) patients in the treatment group were significantly higher than those in the control group (P <0.05). Two groups of patients during the treatment did not appear serious adverse reactions. Conclusion: Chaihu Shugan Powder combined with proton pump inhibitor (PPI) can effectively improve the symptoms of gastroesophageal reflux disease in high altitude areas without adverse reactions.