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目的 探讨乳腺癌患者血浆血管内皮生长因子 (P VEGF)手术前后及发生转移时可能的变化情况及其临床意义。方法 采用酶联免疫吸附试验 (ELISA)检测不同类型的乳腺癌 (39例乳腺浸润性导管癌、2 8例乳腺浸润性小叶癌、9例复发转移性乳癌 )患者P VEGF水平 ,并进行比较分析。结果 术前乳腺浸润性导管癌P VEGF水平明显高于浸润性小叶癌 (P =0 .0 0 0 ) ,与术后 7dP VEGF水平比较无差异(P >0 .0 5 ) ,术后 30dP VEGF水平明显低于术前和术后 7d的水平 (P <0 .0 5 ) ;浸润性小叶癌手术前及手术后 7、30dP VEGF水平比较无显著差异 (P均 >0 .0 5 )。复发转移性乳腺癌P VEGF水平明显高于前二者水平 (P均 <0 .0 5 )。结论 P VEGF在浸润性导管癌中的水平高于浸润性小叶癌中的水平 ,复发转移性乳腺癌的P VEGF水平更高 ,可以作为乳腺癌、尤其是浸润性导管癌复发转移的生物学监测指标
Objective To investigate the possible changes and clinical significance of plasma vascular endothelial growth factor (P VEGF) in patients with breast cancer before and after operation and metastasis. Methods The levels of P-VEGF in different types of breast cancer (39 breast invasive ductal carcinomas, 28 breast invasive lobular carcinomas and 9 recurrent metastatic breast cancer) were detected by enzyme linked immunosorbent assay (ELISA) . Results The P VEGF level in infiltrating ductal carcinoma before operation was significantly higher than that in infiltrating lobular carcinoma (P = 0.0000). There was no significant difference between the two groups (P> 0.05) (P <0.05). There was no significant difference in VEGF levels between preoperative and postoperative 7 and 30 days in invasive lobular carcinoma (P> 0.05). P VEGF levels in recurrent metastatic breast cancer were significantly higher than those in the former two groups (all P <0.05). Conclusions P VEGF is higher in invasive ductal carcinoma than that in invasive lobular carcinoma, and P VEGF in recurrent metastatic breast cancer is higher, which may be used as a biological monitor for the recurrence and metastasis of breast cancer, especially invasive ductal carcinoma index