论文部分内容阅读
心肌氧供/需比例下降时心肌释出的内源性腺苷对缺血心肌具有保护作用。它能减轻再灌注损害,缩小梗塞范围。腺苷与心肌再灌注损害心肌顿抑心肌缺血发作后的持久性心室功能障碍,称为心肌顿抑(myocardial stunning),以别于心肌梗塞后的不可逆性心肌损害。心肌顿抑的特征是,缺血发作后出现代谢和功能异常,可持续数小时乃至数日。可能涉及多种机理。 1.细胞不能产生足够的能量心肌缺血发作后数小时至数日,三磷酸腺苷(ATP)水平下降。心肌缺血时,即使线粒体功能仍完
Endocardial adenosine released by the myocardium at a reduced ratio of myocardial oxygen supply / protection has a protective effect on ischemic myocardium. It can reduce reperfusion damage and reduce infarct size. Adenosine and Myocardial Reperfusion Injury Myocardial stunned myocardial infarction after persistent ventricular dysfunction, known as myocardial stunning (myocardial stunning), in addition to myocardial infarction after irreversible damage. Myocardial stunnedness is characterized by metabolic and functional abnormalities that occur after an ischemic attack and can last for hours or even days. There may be a variety of mechanisms involved. 1. cells do not produce enough energy Myocardial ischemia a few hours to a few days, adenosine triphosphate (ATP) levels decreased. Myocardial ischemia, even if the mitochondrial function is still finished