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目的:探讨婴幼儿反复呼吸道感染(RRTI)与尘螨过敏及体液免疫功能临床关系。方法:80例RRTI婴幼儿全部抽取静脉血检测免疫球蛋白及过敏原点刺试验。根据过敏原点刺试验结果分为阴性组(A组)及阳性组(B组),B组中根据Ig E结果以Ig E正常组(B1组)Ig E增高组(B2组),对照组(C组)20例正常婴幼儿做免疫球蛋白测试。结果:80例中过敏原点刺试验阳性28例,阳性率达35.00%。Ig G在A组、B组相比差异无统计学意义(P>0.05),A组、B组与正常组相比差异有统计学意义(P<0.05)。Ig A、Ig M各组比较差异无统计学意义(P>0.05)。Ig E在A组、C组相比差异无统计学意义(P>0.05),B组与A组及C组比较差异有统计学意义(P<0.01);B组中B1组与B2组比较差异有统计学意义(P<0.01)。结论:RRTI患儿体液免疫功能低下,尘螨过敏是发病因素之一,部分合并有Ig E增高者可加剧气道过敏性,导致慢性炎症,Ig E增高是RRTI发病机制之一,为临床治疗RRTI提供一条新的思路。
Objective: To investigate the clinical relationship between RRTI and dust mite allergy and humoral immune function. Methods: 80 cases of RRTI infants and young children were all drawn venous blood immunoglobulin and allergen prick test. According to allergen prick test results were divided into negative group (A group) and positive group (B group), IgE group B Ig E normal group (B1 group) Ig E increased group (B2 group), control group Group C) 20 normal infants and young children to do immunoglobulin test. Results: Totally 28 cases of allergic prick test were positive in 80 cases, the positive rate was 35.00%. There was no significant difference in Ig G between group A and group B (P> 0.05). The difference between group A and group B was statistically significant (P <0.05). There was no significant difference between Ig A and Ig M groups (P> 0.05). There was no significant difference in Ig E between group A and group C (P> 0.05), but there was significant difference between group B and group A and group C (P <0.01) The difference was statistically significant (P <0.01). Conclusions: Low body fluid immunity and dust mite allergy are one of the pathogenetic factors in RRTI infants. Partially combined with elevated Ig E may aggravate airway hyperresponsiveness, leading to chronic inflammation. Elevated IgE is one of the pathogenesis of RRTI, RRTI provides a new idea.