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采用受体放射性配基结合分析法和生化酶底物反应研究了补肾中药、补肾活血中药对老年大鼠脑组织中胆碱能Ｍ 受体结合容量（Ｒｔ） 与乙酰胆碱酯酶（ＡｃｈＥ） 活性的影响。结果表明：老年大鼠大脑组织中Ｍ 受体Ｒｔ 值较青年大鼠显著低， 而ＡｃｈＥ活性则显著高。补肾中药、补肾活血中药可明显抑制老年大鼠脑组织中ＡｃｈＥ活性， 显著增加Ｍ 受体Ｒｔ 值。提示补肾中药、补肾活血中药可通过降低老年大鼠脑组织中ＡｃｈＥ活性， 增加Ｍ 受体Ｒｔ 值， 延缓脑组织的衰老。
Receptor radioligand binding assay and biochemical enzyme substrate reaction were used to study the cholinergic M-receptor binding capacity (Rt) and acetylcholinesterase (AchE) activity in brain tissue of aged rats. influences. The results showed that the M receptor Rt values in the brain tissue of aged rats were significantly lower than those in young rats, but the AchE activity was significantly higher. Kidney-tonifying traditional Chinese medicine and kidney-tonifying and blood-activating Chinese herbs can significantly inhibit the activity of AchE in the brain of aged rats and significantly increase the M receptor Rt value. Tips Bushen Chinese medicine and Bushen Huoxue Chinese medicine can reduce the AchE activity in the brain of aged rats, increase the M receptor Rt value, and delay the aging of brain tissue.