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目的:观察东莨菪碱对吗啡(Mor)依赖性作用的影响。连续ip吗啡与纳络酮催促建立小鼠依赖模型。结果:吗啡依赖组小鼠痛阈下降,跳跃次数增加,肛温下降。东莨菪碱和阿托品可能与相关脑内吗啡成瘾细胞的胆硷能受体的亲和力不同,阿托品与受体的亲和力低,故不能减轻吗啡的戒断症状;相反,东莨菪碱与受体的亲和力高,故能减轻吗啡的戒断症状。发现东莨菪碱(0.4mg、4mg·kg-1×7d)能明显提高依赖性小鼠的痛阈,减少跳跃次数(率),恢复其肛温。结论:东莨菪碱对抗吗啡致小鼠依赖性的作用。
Objective: To observe the effect of scopolamine on morphine (Mor)-dependent effects. Continuous morphine and naloxone urge the establishment of a mouse-dependent model. RESULTS: In the morphine-dependent mice, the pain threshold decreased, the number of jumps increased, and the rectal temperature decreased. Scopolamine and atropine may have different affinities to the cholesterinergic receptors in the related brain morphine-addicted cells. Atropine has a low affinity with the receptor, so it can not alleviate the withdrawal symptoms of morphine; on the contrary, the affinity of scopolamine and the receptor is high, so Can reduce the withdrawal symptoms of morphine. It was found that scopolamine (0.4mg, 4mg · kg-1 × 7d) can significantly increase the pain threshold of dependent mice, reduce the number of jumps (rate), and restore their rectal temperature. CONCLUSIONS: Scopolamine acts against morphine-induced mice.