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为探讨新生猪缺氧缺血性脑损伤的脑血流变化，将１６只新生猪分为正常、缺氧缺血１５分钟、３０分钟和６０分钟４组，采用脑组织墨汁灌注观察脑组织血管形态和分布，并用体视学分析方法测定脑组织微血管的宽度及体积分数。结果显示：随着缺氧缺血时间延长，细小血管出现不连续断裂，至６０分钟时几不可见毛细血管，仅见少量血管断端呈断树枝状。体视学分析发现，随缺氧缺血时间延长，毛细血管及小静脉宽度逐渐变窄（Ｐ＜０．０５），毛细血管及小静脉体积分数则逐渐缩小（Ｐ＜０．０５）。由此表明，脑血流灌注量的下降在缺氧缺血性脑损伤的发病中起着重要的作用。
In order to investigate the changes of cerebral blood flow in neonatal pigs with hypoxic-ischemic brain damage, 16 newborn pigs were divided into 4 groups: normal, hypoxic-ischemic 15 minutes, 30 minutes and 60 minutes. Morphology and distribution, and using stereological methods to determine the brain tissue microvessel width and volume fraction. The results showed that: with the hypoxia-ischemia time, the small blood vessels appear discontinuous fracture, few to 60 minutes when the capillaries, only a small amount of blood vessels showed broken branches dendritic. Stereological analysis showed that with the extension of hypoxic-ischemic time, the width of capillaries and venules became narrower (P <0.05), while the volume of capillaries and venules decreased gradually (P <0.05). This shows that the decline in cerebral blood flow in the pathogenesis of hypoxic-ischemic brain injury plays an important role.