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法国学者Frerichs氏(1861)首次发现肝脏疾病时尿量减少的现象,以后Chauffatd氏(1885)观察尿量多少作为预后的估价,Pick氏(1923)研究的结果,证明肝脏为利尿的前肾(Vorniere),同年Volhard氏提出水负荷试验,作为肝脏功能检查的一种方法,1939年Nonnenbruch氏描写这种现象称为肝肾综合病征(Hepato-tenalSyndrome),至于肝病尿量减少之机理,前人很少研究,但近年来随着检查技术的进步,在这方面已有不少的成就,据1955—1956年文献报告,肝脏病时水代谢障碍的原因,非常复杂,与下列四种因素有关:
After the French scholar Frerichs (1861) first found a decrease in urine output during liver disease, Chauffatd’s (1885) estimate of the amount of urine used as an estimate of prognosis and the results of Pick’s (1923) study demonstrated that the liver is a diuretic anterior kidney Vorniere), the same year Volhard’s proposed water load test as a method of liver function test, Nonnenbruch’s description of this phenomenon in 1939 called Hepato-tenal Syndrome, as liver cirrhosis reduce the mechanism of urine, Few studies, but in recent years as the inspection technology advances, there have been many achievements in this regard, according to the 1955-1956 literature reported that liver disease caused by water metabolism disorders, very complicated, with the following four factors :