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目的比较人与小鼠胚胎鼻咽部的解剖学和组织学差异,为研究一些鼻咽部疾病发病机制提供参考资料。方法用组织学方法观察E9-28周人胚胎及E9.5~19.5 d C57BL/6J小鼠胚胎鼻咽结构及粘膜形态。结果人胚胎鼻咽部呈不规则的立方形,顶后壁呈约120°的弧形;鼻咽部富含皱襞、隐窝及淋巴组织。小鼠鼻咽部是一个接近直线的弧形管腔,无淋巴组织及隐窝等结构。人胚胎鼻咽粘膜早、中期主要是假复层纤毛柱状上皮被覆,只有少量过渡上皮及复层鳞状上皮存在。小鼠胚胎鼻咽粘膜全部为假复层纤毛柱状上皮。结论人与小鼠胚胎鼻咽解剖学和组织学差异,可能导致他们对某些疾病易感性不同。
Objective To compare the anatomy and histology of nasopharyngeal between human and mouse embryos and provide references for studying the pathogenesis of some nasopharyngeal diseases. Methods The histopathology was used to observe the nasopharyngeal structure and mucosal morphology of E9-28 week embryos and E9.5 ~ 19.5 d C57BL / 6J mice. Results The nasopharynx of human embryo showed an irregular cubic shape with an arc of about 120 ° on the posterior wall. The nasopharynx was rich in folds, crypts and lymphoid tissues. Mouse nasopharynx is a straight arc of the lumen, no lymphatic tissue and crypt and other structures. Human embryonic nasopharyngeal mucosa early and mid-term is mainly pseudostratified ciliated columnar epithelium, only a small amount of transitional epithelial and stratified squamous epithelium exist. Mouse embryos nasopharyngeal mucosa pseudostratified ciliated columnar epithelium. Conclusions Differences in nasopharyngeal anatomy and histology between human and mouse embryos may lead to their different susceptibility to certain diseases.