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目的：阐明低密度脂蛋白（ＬＤＬ）分子颗粒与脑动脉粥样硬化之间的内在关系。方法：以胆固醇负荷家兔为动物模型，从血浆ＬＤＬ的脂质生化学和超微形态学的角度对其进行动态观察。结果：随着胆固醇负荷时间的增加，血浆ＬＤＬ中脂质过氧化物（ＬＰＯ）和载脂蛋白Ｂ（ＡｐｏＢ）的含量逐渐增加，血浆ＬＤＬ分子颗粒也明显增大。结论：血浆ＬＤＬ分子颗粒的增大可能是引起脑动脉粥样硬化形成的原因之一。因此，膳食结构的改变可以预防和阻止脑动脉粥样硬化的形成。
Objective: To elucidate the intrinsic relationship between low density lipoprotein (LDL) molecular particles and cerebral atherosclerosis. Methods: Cholesterol-loaded rabbits were used as animal models to observe the dynamic changes of plasma LDL from lipid biochemistry and ultrastructure morphology. Results: With the increase of cholesterol load time, the content of LPO and ApoB in plasma LDL gradually increased, and the plasma LDL molecular particles also increased obviously. Conclusion: The increase of plasma LDL particles may be one of the causes of cerebral atherosclerosis. Therefore, dietary changes can prevent and prevent the formation of cerebral atherosclerosis.